ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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Carbapenems can reduce serum concentrations of valproic acid to subtherapeutic levels when the two drugs are administered together. Practitioners should be aware that antibiotic-associated colitis has been observed to occur over two months or more following discontinuation of systemic antibiotic therapy; a careful medical history should srtapenem taken.

Dilute the entire contents of the reconstituted vial in 50 mL of 0. It inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins PBPs that are located inside the bacterial cell wall.

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. It exhibits non-linear pharmacokinetics due to a high level of concentration-dependent plasma protein binding to albumin.

Guidelines recommend ertapenem for mixed necrotizing infections. In animal studies evaluating doses 1.

Shake well to dissolve. It is eliminated via the kidney with a prolonged half-life of roughly 4. A supplemental dose may or may not be required following dialysis. Patients should be told to complete the full course of treatment, even if they feel better earlier.

There packwge a maximum proportion of PBPs that can be acylated; therefore, once maximum acylation has occurred, killing rates cannot increase. Do not co-infuse with other medications. Prior to initiating ertapenem therapy, the patient pcakage be carefully questioned about previous penicillin hypersensitivity, cephalosporin hypersensitivity, allergic reactions to other beta-lactams e. Products inhibiting ertxpenem are contraindicated in this clinical situation.

Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives. If ertapenem is given 6 hours or more prior to hemodialysis, no supplemental dosing is required.

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It is known that systemic use of antibiotics predisposes patients to development of pseudomembranous colitis. For the treatment of complicated intraabdominal infections.

Anticonvulsant therapy should be initiated if indicated and the dose of ertapenem should be re-evaluated based on the patient’s renal function.

Safety and efficacy have not been established. The IM reconstituted formulation is not for IV use.

Invanz (ertapenem) dose, indications, adverse effects, interactions from

Consider transitioning to an appropriate oral therapy after at least 3 days of parenteral therapy, once clinical improvement has been demonstrated. Ertapenem solution is colorless to pale yellow; variations of color within this range do not affect the potency of the product.

Ertapenem should be prescribed with caution to patients with inflammatory bowel disease such as ulcerative colitis or other GI disease. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy ertapeneem OCs and antibiotics was reported.

It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, ertapdnem, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs.

Monitor patients for signs and symptoms of bleeding. However, it is theorized that a combination of resistance mechanisms is required for significant carbapenem resistance. Additionally, increased monitoring of the INR, especially during initiation and upon discontinuation of the antibiotic, may be necessary.

No data are available regarding use in pediatric patients with renal impairment. For the treatment of complicated urinary tract infection UTI pyelonephritisincluding cases with concurrent bacteremia. Immediately transfer the appropriate amount of the reconstituted vial to diluent. However, specific intrinsic or acquired beta-lactamases, generally called carbapenemases, can hydrolyze the carbapenems.

For less than 1 g dose: Immediately withdraw the appropriate dose and inject deeply into a large muscle i. By day 5 after discontinuation, the concentration in breast milk was undetectable. Minor Probenecid inhibits the renal excretion of ertapenem by competing with them for active tubular secretion. Accumulation does not occur following multiple IM doses in healthy adults. During long-term antibiotic administration, the risk for inserrt interaction with OCs is less clear, but alternative or additional pckage may be advisable in selected circumstances.

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Anticonvulsive therapy should be continued in patients packahe a known seizure disorder. Major Prior or concomitant use of antibiotics with sodium picosulfate; magnesium oxide; anhydrous citric acid may reduce efficacy of the bowel preparation as conversion of sodium picosulfate to its active metabolite bis- p-hydroxy-phenyl -pyridylmethane BHPM is mediated by colonic bacteria.

Valproic Acid, Divalproex Sodium: Most patients with skin and soft tissue infections do well with 1 to 2 weeks of eertapenem. The diluted solution may be refrigerated for up to 24 hours 5 degrees C and used within 4 hours after removal from refrigeration.

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Based on the study results, these authors recommended that back-up contraception may not be necessary if OCs are used reliably during oral antibiotic use. For the treatment of complicated skin and skin structure infections, including diabetic foot infections diabetic foot ulcer. Data regarding progestin-only contraceptives or for newer combined contraceptive deliveries e. Carbapenem hypersensitivity, cephalosporin hypersensitivity, penicillin hypersensitivity.

This drug is not an effective treatment for a viral infection e. Following diagnosis of pseudomembranous colitis, therapeutic measures should be instituted. Other dosage adjustment erfapenem for adults: In moderate to severe cases, fluids and electrolytes, protein supplementation, and treatment with pzckage antibacterial effective against Clostridium difficile may be warranted.

Clinical trial data and other reported clinical experience has not identified differences in responses between the elderly and younger adult patients, but greater sensitivity of some older individuals cannot be ruled out.

Ertapenem is not a substrate for P-glycoprotein mediated transport. In milder cases, the colitis may respond to discontinuation of the ;ackage agent.